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/ Indicative Syllabus Process of developing a drug: from bench to a product including Product Life Cycle Management and tools (14 hours) • In vitro activity • In vivo activity • Pharmacokinetics (ADME) and toxicity • Pre-clinical trial • Clinical trial phase I, II and III • Cost estimation of each stage Innovation (4hrs) -- 1 of 3 -- Importance of patents in biotechnology (4 hours) • Different kinds of patents: Utility, Design, Plant, or Provisional Patent. • Writing Descriptions, Claims, or Abstracts for a patent application • Brief introduction to different regulatory bodies around the world. Business plan (4 hours) • Purpose of a business plan. • Different components of a business plan • Writing your own business to raise funding for a start-up biotech company
/ Indicative Syllabus 1. natural environments, and their physical and chemical processes such as cycling of water and nutrients; 2. ecological processes and evolution, which describe the ecological diversity, speciation/extinction, interactions among species at different levels of the ecological hierarchy and their adaptation to the environments; 3. major ecosystems, ranging from macrosystems (terrestrial, aquatic and extreme environments) to microbial systems; 4. adverse environmental impacts caused by humans, such as global climate change and ocean acidification, along with pollution of heavy metals, persistent organic pollutants and microplastics; and 5. environmental conservation and sustainability, which explains the principles and methods in environmental monitoring, renewable energy options, novel food production in the face of environmental changes, and ecological restoration by humans as an example of positive environmental impacts. -- 1 of 2 --
/ Indicative Syllabus Process of developing a drug: from bench to a product including Product Life Cycle Management and tools • In vitro activity • In vivo activity • Pharmacokinetics (ADME) and toxicity • Pre-clinical trial • Clinical trial phase I, II and III • Cost estimation of each stage Importance of patents in biotechnology • Different kinds of patents: Utility, Design, Plant, or ProvisionalPatent. • Writing Descriptions, Claims, or Abstracts for a patent application • Brief introduction to the US Patents and Trademark Office, World Intellectual Property Organization (wIPO)and State Intellectual Property Office of the People’s Republic of China Business plan • Purpose of a business plan. • Different components of a business plan • Writing your own business to raise funding for a start-up biotech company -- 1 of 3 -- 2
/ Indicative Syllabus Diagnostic technology and biomarkers in Chemical Pathology: • Principles and application of spectrophotometry, immunochemistry, electrochemistry, osmometry, enzymology, electrophoresis, chromatography, mass spectrometry, molecular diagnostic technologies • Common biomarkers and influencing factors • Point-of-care testing Method validation and quality assurance: • Instrument maintenance, calibration, quality control, quality assurance and accreditation • Precision, accuracy, Levy Jennings chart, Westgard Rules and types of errors • Test method validation and data analysis Biomarker measurement and result interpretation in various health conditions with associated case studies: • Glucose tolerance and glycaemic control • Renal diseases and renal function tests (RFT), water & electrolyte balance • Acid-base balance & blood gases
/ Indicative Syllabus Haematopoiesis: • Origin of erythrocytes, leukocytes and thrombocytes • Blood cells maturation Erythrocytes and haemoglobin: • Production, structure and function of normal erythrocytes • Morphology of erythrocytes • Pathophysiology of red blood cells and haemoglobin disorders, such as anaemia; thalassaemia; malaria Leucocytes: • Production, structure and function of normal leucocytes • Morphology of leucocytes • Pathophysiology of white blood cells, such as infectious mononucleosis, leukaemia; multiple myeloma Laboratory investigation of erythrocyte and leucocyte disorders: • Sample collection and preparation for haematological diagnostic tests -- 1 of 3 -- • Preparation and examination of peripheral blood film • Complete blood counts, differential counts and red cell indices • Automations in haematology • Erythrocyte sedimentation rate (ESR) • Reticulocyte count • Haemoglobin pattern analysis • Molecular investigation of blood diseases Haemostasis: • Production, structure and function of normal platelets • Morphology of platelets • Haemostatic mechanism • Abnormalities in blood coagulation, fibrinolysis, and platelet activation • Laboratory investigation of haemostatic disorders • Laboratory monitoring of therapeutic anticoagulation Transfusion Science: • Immunohaematology • Clinical use blood component preparation and storage • Blood-banking techniques • Pretransfusion testing and post-transfusion reaction investigation • Laboratory investigation of haemolytic anaemia
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暂无评分/ Indicative Syllabus Normal histology: • Normal structure of basic tissue types and their functions • Normal tissue structure of major organ systems, such as circulatory, skin, skeletal, respiratory, digestive, lymphoreticular, urinary, reproductive and central nervous system. Tissue preparation and processing: • Fixation and preservation • Decalcification • Tissue processing • Microtomy and cryostat sectioning • Mounting Laboratory techniques to demonstrate tissue structures and elements: • General tissue structure staining techniques • Special staining techniques for demonstration of connective tissues, carbohydrates, lipids, nucleic acids, pigments, amyloid, microorganisms, bone, etc. -- 1 of 3 -- • Immunohistochemistry (IHC) and immunocytochemistry (ICC) • Enzyme histochemistry • Molecular diagnosis in Anatomical Pathology Histopathology: • Basic concepts in identification of abnormal cells and pathological features in tumours and malignancy Cytology: • Sample collection and processing • Cytological smear preparation and staining • Cytological features of normal cellular constituents, common changes shown in cells in relation to disease and associated malignancy
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暂无评分/ Indicative Syllabus INDICATIVE CONTENT • Principles & practices of chromatography – permeation, ion- exchange, affinity chromatography; gas chromatography; HPLC; separation of biomolecules 6 hours • Electrophoresis: principles and general techniques; special techniques-high voltage discontinuous, SDS-polyacrylamide, gradient, isoelectric focusing, two-dimensional electrophoresis and western blotting 6 hours • Fluorescence pri ncipl e and its applications; flow cytometry 8 hours • DNA microarray 2 hours • DNA sequencing and fingerprinting 2 hours • Luminescence and chemiluminescence; luciferase, green fluorescent protein 2 hours • Real-time PCR 2 hours • Sample preparation: cell disruption, buffer, dialysis, concentration methods, measurement of proteins and nucleic acids 2 hours • Centrifugation and subcellular fractionation 2 hours -- 1 of 3 --
/ Indicative Syllabus • Principles & practices of chromatography – permeation, ionexchange, affinity chromatography; gas chromatography; HPLC; separation of biomolecules • Electrophoresis: principles and general techniques; special techniques-high voltage discontinuous, SDS-polyacrylamide, gradient, isoelectric focusing, two-dimensional electrophoresis and western blotting • Fluorescence principle and its applications; flow cytometry • DNA microarray • DNA sequencing and fingerprinting • Luminescence and chemiluminescence; luciferase, green fluorescent protein -- 1 of 3 -- 2 • Real-time PCR • Sample preparation: cell disruption, buffer, dialysis, concentration methods, measurement of proteins and nucleic acids • Centrifugation and subcellular fractionation
/ Indicative Syllabus • Principles & practices of chromatography – permeation, ion exchange, affinity chromatography; gas chromatography; HPLC; separation of biomolecules • Electrophoresis: principles and general techniques; special techniques-high voltage discontinuous, SDS-polyacrylamide, gradient, isoelectric focusing, two-dimensional electrophoresis and western blotting • Fluorescence principle and its applications; flow cytometry • DNA microarray • DNA sequencing and fingerprinting • Luminescence and chemiluminescence; luciferase, green fluorescent protein • Real-time PCR -- 1 of 2 -- 2 • Sample preparation: cell disruption, buffer, dialysis, concentration methods, measurement of proteins and nucleic acids • Centrifugation and subcellular fractionation
/ Indicative Syllabus Students will be presented with a problem or task that requires the use of at least the following molecular biology and biochemical techniques: (a) Site-directed mutagenesis using PCR, restriction digestion, plasmid cloning vectors; (b) Transformation into bacterial cells for amplification and purification from bacterial cells; (c) Protein expression, extraction, purification and characterizations; (d) DNA gel electrophoresis, Protein SDS-PAGE, DNA sequencing; (e) Study of protein modification and its implications Students will be asked to plan experiments and present it in the form of a proposal. Students will carry out the experiments involving the above techniques and collect data from their work. Students will meet tutors frequently to discuss the experiment progress and finalize details of coming laboratory work. Students will write up a report to present their work and findings. Students will present a scientific article in front of the whole class.
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暂无评分/ Indicative Syllabus Measurement of Water Quality Parameters Hardness and Nitrate COD Preparation of poly(methyl methacryalate) (PMMA) into a sheet via a free radical polymerization of methyl methacrylate and evaluation of the polymer properties. Characterization of polymers using differential scanning calorimetry (DSC) Measurement of polymer molecular weight with dilute-solution viscosity method -- 1 of 3 --
/ Indicative Syllabus Definition of general terms and classification of polymers 2 hours Chain growth polymerization: free radical polymerization including initiation, propagation, termination and chain transfer; types of initiator; Stereochemistry of polymer; ceiling temperature; comparison of bulk, solution, suspension and emulsion polymerization systems; Other chain growth polymerization: Anionic polymerization; cationic polymerization; coordination polymerization. 8 hours 4 hours Step growth polymerization: Various condensation polymerization methods and their formation mechanism. 6 hours -- 1 of 4 -- These include different commercially important polymers such as Phenol-, Urea-, and Melamine- Formaldehyde Resins; Polyesters; Polycarbonates; Polyamides; and polyurethanes Factors affecting polymer properties: types of average relative molar mass and methods to determine this property; crystalline and amorphous regions; phase transitions in polymers; intermolecular forces; glass transition and melting temperatures 6 hours Mechanical and thermal properties: thermal analysis; mechanical properties of polymers and their measurement 3 hours Fabrication techniques: injection moulding; compression moulding; extrusion; blow moulding; RIM; additives, degradation of polymers 4 hours
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暂无评分/ Indicative Syllabus Atmosphere Atmospheric structure, atmospheric chemistry. Sources and effects of particulates, oxides of sulphur, CO and CO2, oxides of nitrogen and air-borne lead. Freons and the depletion of stratospheric ozone. Photochemical smog. Greenhouse effect and global warming. Hydrosphere Chemistry of natural waters. Water quality, supply and demand of drinking water, management. Water pollution, sources of industrial and agricultural water pollution, organic and inorganic pollutants. Water quality analysis. CO 2 equilibrium, carbonate systems, acid rain. Water and Wastewater Treatment. -- 1 of 3 -- Lithosphere Nature of soil, soil chemistry, and wastes and pollutants in soil. Biogeochemical Cycles The Carbon and Oxygen cycles
/ Indicative Syllabus 1. Concepts of ecology Evolution; natural selection; biodiversity; extinction and speciation; levels of biological organization 2. Communities and ecosystems Physical environments; organism interactions; ecosystem functions and services; characteristics of key ecosystems 3. Environmental mechanisms The water cycle; trophic transfer of energy; production and decomposition; nutrient cycling 4. Ecological monitoring and conservation Anthropogenic stress; environmental deterioration; ecological restoration; ecological
/ Indicative Syllabus Properties of Gases Simple gas laws, Ideal Gas Equation and its application, non-ideal gases Electrons in Atoms Electromagnetic radiation, atomic spectra, hydrogen atom and many electron atoms, electronic configurations Periodic Table and Atomic Properties Classification of chemical elements, sizes of atoms and ions, ionization energy, electronic affinity, magnetic properties, periodic properties of the elements Chemical Bonding – Localized Electron Pair Approach Lewis theory and Octet rule, limitation of the Lewis theory, bond energies and bond distances, polar covalent bonds, VSEPR theory and molecular shapes of polyatomic molecules, physical properties and Intermolecular Forces and Properties of Liquids and solids Dipole-dipole interaction, ion-dipole interaction, van der Waals forces, hydrogen bonding, physical properties of liquidand solids. -- 1 of 3 -- Chemistry of Transition Metals Electronic configurations and general properties of transition metals; co- ordination compounds; ligands and co-ordination numbers; Electroanalytical Chemistry Brief review of Faraday Processes; Fundamental concepts of the electrical double layer; Phenomena associated with the properties of the double layer with adsorption. The Tafel equation and its interpretations of overpotentials; Kinetics of electrode reactions; Electrocatalysis; Mass transfer by migration, diffusion and forced convection.
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暂无评分/ Indicative Syllabus Laboratory Safety The PolyU Health and Safety Policy; General laboratory safety practices; Hazards and risk
/ Indicative Syllabus Molecular Spectroscopy UV-Visible spectroscopy: the electromagnetic spectrum; Beer’s Law; methodologies in quantitative analysis; instrumentation. Infrared spectroscopy: sample preparation; instrumentation; absorption wavelengths of common functional groups; applications; near infrared spectroscopy; Fourier-transform infrared spectroscopy. Raman spectroscopy: principle; instrumentation; applications. Fluorescence spectroscopy: principle; instrumentation; applications. Nuclear magnetic resonance spectroscopy: principle, proton NMR, carbon-13 NMR, applications. Atomic Spectroscopy Atomic Emission and Absorption Spectrophotometry: review of Beer’s Law of light absorption; components of an atomic absorption/emission spectrophotometer; the flame and graphite furnace atomizer; the inductively-coupled plasma excitation source; interference effects; applications.
/ Indicative Syllabus General Principles and Basic Techniques of Separation Filtration; Crystallization; Distillation; Extraction; Paper Chromatography; Thin-layer Chromatography; Column Chromatography. High-Performance Liquid Chromatography Basic instrumentation; silica gel, bonded phase normal and reverse-phase packings; UV, fluorescence and MS detectors; Ion-exchange, size- exclusion, and affinity chromatography; new liquid chromatographic techniques. Gas Chromatography Basic instrumentation; types of columns; choice of stationary phases; properties of thermal-conductivity, flame ionization and electron capture detectors; temperature-programming; qualitative and quantitative analytical methodology. Fundamentals of Chromatography The chromatographic process; capacity factor and retention times; column efficiency and resolution; general chromatographic theory. Sample Preparation for Chromatographic Analysis Homogenization; extraction; cleanup.
/ Indicative Syllabus 1. Separation of color pigments by paper and column chromatography 2. Derivation of fatty acids and their determination by gas chromatography 3. Analysis of sugars in beverages using high performance liquid chromatography equipped with reflective index detector 4. Analysis of vitamins by high performance liquid chromatography equipped with fluorescent detector 5. Analysis of aromatic compounds by high performance liquid chromatography 6. Determination of metal ions in soft drink using ion chromatography